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GR43175,a selective 5-HT1-like agonist,was given an intravenous infusion in an open dose-ranging study to treat 46 attacks of severe migraine in 34 patients.The highest dose,2mg infused over 10 min in 24 severe attacks, resulted in rapid and complete relief of symptoms in 17 attacks(71%)and in improvement to a non-migrainous residual headache in 7 attacks.Treatment was well tolerated,the only adverse effects being transient feelings of heaviness and pressure,predominantly in the head.GR43175 may represent an important advance in the treatment of acute migraine. |
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